Cholesterol Support

What it is. Bergamot is a citrus fruit grown primarily in southern Italy. Its extract contains unique polyphenols — including brutieridin and melitidin — not found in other citrus fruits. These compounds have structural similarities to statins.

What it does. Bergamot polyphenols inhibit HMG-CoA reductase — the same enzyme targeted by pharmaceutical statin drugs — reducing the rate of hepatic cholesterol synthesis. Clinical trials have demonstrated dose-dependent reductions in LDL and triglycerides.

Why we include it. Bergamot provides natural HMG-CoA reductase inhibition — supporting healthy cholesterol synthesis without the nutrient depletion concerns associated with pharmaceutical approaches.

What it is. Berberine is a naturally occurring alkaloid found in several plants including Berberis and goldenseal. It is one of the most extensively researched botanical compounds for metabolic and cardiovascular support.

What it does. Berberine activates AMPK and upregulates LDL receptor expression in the liver — increasing the clearance of LDL cholesterol from circulation. It also supports healthy triglyceride levels and glucose metabolism.

Why we include it. Berberine complements bergamot by addressing LDL clearance rather than synthesis — together they support healthy cholesterol levels through two distinct mechanisms.

What it is. Red Yeast Rice is produced by fermenting rice with Monascus purpureus yeast. This fermentation produces monacolin K — a compound identical to the pharmaceutical lovastatin.

What it does. Monacolin K inhibits HMG-CoA reductase, reducing hepatic cholesterol synthesis. Red yeast rice has been used in traditional Chinese medicine for centuries and has substantial clinical evidence for supporting healthy cholesterol levels.

Why we include it. Red Yeast Rice provides standardized, predictable HMG-CoA reductase inhibition — working synergistically with bergamot to support healthy cholesterol synthesis.

What it is. Acetyl-L-Carnitine is an acetylated form of L-carnitine involved in fatty acid transport and metabolism. It shuttles fatty acids into mitochondria for energy production.

What it does. ALCAR supports healthy lipid metabolism by facilitating the transport and oxidation of fatty acids. It has been shown in research to support healthy HDL levels and triglyceride metabolism.

Why we include it. ALCAR supports the utilization of fatty acids for energy — promoting healthy lipid metabolism and supporting the HDL side of the cholesterol equation.

What it is. Myo-Inositol is involved in cellular signaling and lipid metabolism. It is a component of cell membranes and plays a role in insulin signal transduction.

What it does. Myo-Inositol supports healthy lipid metabolism and has been shown to improve lipid profiles in clinical research. It also supports the insulin sensitivity that influences how the body handles dietary fats.

Why we include it. Myo-Inositol addresses the metabolic factors that influence lipid handling — supporting healthy cholesterol levels through improved metabolic function.

What it is. Oleuropein is the primary bioactive polyphenol in olive leaves and oil — the compound most associated with the cardiovascular benefits of the Mediterranean diet.

What it does. Oleuropein protects LDL particles from oxidation — the process that makes LDL harmful to arterial walls. Oxidized LDL, not LDL itself, is most directly implicated in cardiovascular concerns.

Why we include it. Oleuropein addresses LDL quality rather than just quantity — protecting LDL particles from the oxidation that drives cardiovascular risk.

What it is. DHA is a long-chain omega-3 fatty acid with documented effects on lipid metabolism and cardiovascular health.

What it does. DHA supports healthy triglyceride levels and has been shown to improve the size and density profile of LDL particles — shifting toward larger, less atherogenic particles.

Why we include it. DHA supports healthy triglyceride levels and improves LDL particle characteristics — addressing lipid health beyond simple cholesterol numbers.

What it is. EPA is an omega-3 fatty acid with potent effects on triglyceride metabolism and inflammatory balance in vascular tissue.

What it does. EPA has the most robust clinical evidence for triglyceride reduction among omega-3 fatty acids. It also supports healthy inflammatory balance in arterial walls and reduces platelet aggregation.

Why we include it. EPA provides the strongest omega-3 support for triglyceride metabolism — complementing the cholesterol-focused ingredients with targeted triglyceride support.