Inflammation Support

What it is. Boswellia serrata resin — commonly known as frankincense — has been used in traditional medicine for centuries. Modern research has identified boswellic acids, particularly AKBA, as the active anti-inflammatory compounds.

What it does. AKBA selectively inhibits 5-lipoxygenase (5-LOX) — the enzyme responsible for synthesizing leukotrienes, a class of potent pro-inflammatory molecules. Unlike NSAIDs, Boswellia does not inhibit COX enzymes and therefore does not carry the same gastrointestinal risks.

Why we include it. Boswellia provides targeted 5-LOX inhibition — addressing leukotriene-mediated inflammation through a mechanism distinct from conventional anti-inflammatory approaches.

What it is. Quercetin is one of the most abundant flavonoids in the diet with potent anti-inflammatory properties targeting multiple inflammatory pathways.

What it does. Quercetin inhibits NF-κB — the master transcription factor that controls the expression of pro-inflammatory cytokines, chemokines, and adhesion molecules. It also stabilizes mast cells and has antioxidant properties.

Why we include it. Quercetin addresses inflammation at the transcriptional level — inhibiting the master switch that turns on inflammatory gene expression.

What it is. Alpha Lipoic Acid is a unique antioxidant that is both water-soluble and fat-soluble, allowing it to neutralize free radicals throughout the cell and reduce oxidative stress-driven inflammation.

What it does. ALA inhibits NF-κB activation, reduces inflammatory cytokine production, and regenerates other antioxidants including glutathione. It addresses the oxidative stress that both triggers and amplifies inflammatory signaling.

Why we include it. ALA addresses the oxidative-inflammatory cycle — reducing the oxidative stress that drives inflammatory signaling while also directly inhibiting NF-κB.

What it is. Ashwagandha has documented anti-inflammatory properties in addition to its adaptogenic effects. Its withanolides inhibit inflammatory pathways and reduce stress-induced inflammation.

What it does. Ashwagandha reduces CRP and other inflammatory markers, inhibits NF-κB and COX-2 pathways, and addresses the stress-inflammation connection through HPA axis modulation.

Why we include it. Ashwagandha addresses the stress-inflammation axis — reducing both the physiological stress response and the inflammatory signaling it triggers.

What it is. Astragalus contains polysaccharides and saponins with documented anti-inflammatory and immune-modulating properties.

What it does. Astragalus modulates inflammatory cytokine production, supports healthy inflammatory resolution, and has antioxidant properties that reduce oxidative stress-driven inflammation.

Why we include it. Astragalus supports balanced inflammatory response — modulating rather than suppressing inflammation to support healthy resolution.

What it is. Propolis contains over 300 bioactive compounds including flavonoids and phenolic acids with potent anti-inflammatory properties.

What it does. Propolis inhibits NF-κB, reduces pro-inflammatory cytokine production, and has been shown to reduce inflammatory markers in clinical studies. Its diverse bioactive profile addresses inflammation through multiple mechanisms.

Why we include it. Propolis provides broad-spectrum anti-inflammatory support through its diverse array of bioactive compounds — complementing the targeted mechanisms of other ingredients.

What it is. Vitamin C is a potent antioxidant that reduces oxidative stress and has direct anti-inflammatory effects through multiple mechanisms.

What it does. Vitamin C reduces CRP and other inflammatory markers, neutralizes reactive oxygen species that trigger inflammation, and supports the function of immune cells involved in inflammatory resolution.

Why we include it. Vitamin C addresses the oxidative component of inflammation — reducing the free radical burden that amplifies inflammatory signaling.

What it is. Vitamin D3 has potent immunomodulatory effects, helping to balance inflammatory response rather than simply suppressing it.

What it does. Vitamin D3 inhibits NF-κB, reduces pro-inflammatory cytokine production, and supports regulatory T-cell function — the immune cells responsible for preventing excessive inflammatory response.

Why we include it. Vitamin D3 supports inflammatory regulation at the immune cell level — helping the immune system mount appropriate but not excessive inflammatory responses.

What it is. Vitamin B6 status is inversely associated with inflammatory markers — higher B6 is linked to lower inflammation across population studies.

What it does. B6 is required for the metabolism of homocysteine (elevated homocysteine drives inflammation) and supports the synthesis of anti-inflammatory compounds. Deficiency is associated with elevated CRP and IL-6.

Why we include it. B6 addresses the nutritional factors that influence baseline inflammatory status — supporting the metabolic pathways that keep inflammation in check.

What it is. DHA is an omega-3 fatty acid that incorporates into cell membranes and is converted to specialized pro-resolving mediators that actively resolve inflammation.

What it does. DHA reduces inflammatory cytokine production, supports the resolution of inflammation, and competes with arachidonic acid for inflammatory enzyme pathways — reducing pro-inflammatory eicosanoid production.

Why we include it. DHA supports both the reduction of inflammatory signaling and the active resolution of inflammation — addressing both phases of the inflammatory process.

What it is. EPA is the primary omega-3 fatty acid for anti-inflammatory effects and the precursor to resolvins — specialized compounds that actively resolve inflammation.

What it does. EPA competes with arachidonic acid for COX and LOX enzymes, reducing pro-inflammatory prostaglandin and leukotriene production. It is converted to E-series resolvins that actively promote inflammatory resolution.

Why we include it. EPA provides the most direct omega-3 anti-inflammatory support — both reducing inflammatory mediator production and generating pro-resolving compounds.